The Cardiovascular Theme has a foundation deeply rooted in the long and proud history of research excellence at UCLA. We encourage your feedback and inquiries as you get to know the Cardiovascular Theme and invite you to be a part of the UCLA mission to transform cardiovascular health.
Yibin Wang, PhD
Cardiovascular Theme Chair
Professor of Anesthesiology, Medicine & Physiology
Dr. Wang’s research mainly focuses on genetic and molecular mechanisms of heart failure and metabolic disorders. His lab has made major advances in uncovering stress-signaling mechanisms in the pathogenesis of heart failure, and revealed functional importance amino acids catabolism in heart failure and metabolic disorders. In addition, his lab reported novel regulatory mechanisms in cardiac transcriptome reprogramming involving RNA splicing regulation and non-coding RNA mediated epigenetic modulation.
James N Weiss, MD
Cardiovascular Theme Co-Chair
Chizuko and Nobuyuki Kawata Chair in Cardiology
Dr. James Weiss focuses his research on ion channel biophysics, cardiac electrophysiology, arrhythmias, and ischemia and mitochondrial biology. He leads an interdisciplinary group combining mathematical and experimental biology. He holds memberships in numerous professional organizations, including the American Heart Association, American College of Cardiology, the Heart Rhythm Society, the Biophysical Society, the American Society of Clinical Investigation, the Association of University Cardiologists.
We are pleased to announce the 2018 David Geffen School of Medicine (DGSOM) Seed Grant Program, which was jointly organized by the DGSOM Research Themes, the Institute of Precision Health (IPH), and the Clinical and Translational Science Institute (CTSI). The Strategic Vision for this year’s program and a brief description of its structure follow, and more detailed information and application instructions can be found on the seed grant website: http://medschool.ucla.edu/seed-grant-program. As indicated on the website, teams of faculty from across the UCLA campus are eligible to apply.
Kelsey C. Martin
Stephen T. Smale
Vice Dean, Research
Strategic Vision. The David Geffen School of Medicine (DGSOM) Research Themes have been charged with increasing the impact of basic, translational, clinical, and community research at UCLA in high-priority and broadly defined biomedical research areas. In addition, the Institute of Precision Health (IPH) has been aggressively building an infrastructure for collecting genetic information for a broad range of UCLA patients; IPH seeks to identify diverse research projects that either take advantage of this infrastructure or focus on the development of alternative precision health strategies for advancing knowledge and improving patient care.
Many DGSOM researchers are already immersed in highly impactful research funded by individual grants and contracts to established laboratories, or by start-up funds provided to new laboratories. However, to address many of the most important unanswered questions in biology and the most significant unmet needs in medicine, the diverse expertise found in multidisciplinary teams of investigators will be required. The assembly of outstanding, multidisciplinary teams is challenging because investigators often are required to reach outside of their comfort zones and interact effectively with researchers with very different areas of expertise, or across the basic/translational/clinical/community research spectrum. Importantly, large team science grants from government agencies and private foundations often require evidence that a team has already established productive interactions.
2018 DGSOM Seed Grant Program. In recognition of the strategic vision described above, and in collaboration with the UCLA Clinical and Translational Science Institute (CTSI), the DGSOM Research Themes and the IPH have elected to focus the 2018 DGSOM Seed Grant Program on an effort to promote the assembly of teams of scientists that are well-positioned to perform innovative, high-impact research and ultimately compete for large team science grants from federal agencies and private foundations. Applications are encouraged from faculty throughout the UCLA campus in any biomedical or medical research area in which groundbreaking advances catalyzed by teams of researchers can be envisioned. Applications that take advantage of the infrastructures established by the IPH and CTSI are especially encouraged, as are applications that span disciplines or span the basic, translational, clinical, and community spectrum.
Because the assembly of multidisciplinary teams requires a substantial amount of time, thought, and effort, the 2018 Seed Grant application process will include two phases. In the first phase, brief applications for small Planning Grants will be requested and evaluated (submission deadline, February 4, 2018; see specific instructions at http://medschool.ucla.edu/seed-grant-program, please scan down to section entitled Planning Grant Application Instructions). Successful applicants will be awarded up to $1,000 (by February 15, 2018) to help fund team science planning activities, including internal meetings, brainstorming sessions, and/or workshops over a 3-month time period. These activities should be aimed at identifying key members of the team, developing a cutting-edge research plan, and identifying specific external funding opportunities that can be pursued at the conclusion of the seed funding period.
In the second phase of the application process, Full Grant applications (submission deadline, May 15, 2018) requesting up to $250,000 of direct costs will be submitted. These applications will be restricted to Lead PIs who were awarded a Planning Grant. In addition to a 3-page research proposal, the Full Grant application will include one or two paragraphs describing why the proposed project is timely and compelling, a description of specific future extramural team-science funding opportunities that are anticipated, and a summary of the team assembly activities carried out during the three-month planning period (see specific instructions at http://medschool.ucla.edu/seed-grant-program, and scan down to section entitled Full Grant Application Instructions).
The earliest funding date will be August 1, 2018 and a total investment of up to $3 million is envisioned.