Explore Research Innovation at the David Geffen School of Medicine
Pathogens and people are caught in evolutionary tug-of-war. Having developed alongside humans, infectious agents had plenty of time to observe, learn, and respond to our biological defenses and even our invented safeguards, such as antibiotics. To ensure survival, humans must constantly adapt by innovating novel ways to fight infection.
UCLA Immunity, Inflammation, Infection, & Transplantation (I3T) scientists believe we can better fight infection by studying pathogens in more detail than ever.
What if we could find new ways to fight infection by learning more about it?
What if we knew more about pathogens than they could ever know about us? By learning how infection works on a molecular level, scientists can create highly targeted infection-fighting strategies to replace antibiotic blitz approaches. These balanced, sustainable strategies aim to fight specific pathogens while circumnavigating factors that lead to resistance.
One day, scientists might know enough about the mechanisms of infection to stop ailments before they start.
I3T scientists study the mechanisms and structures driving infection in groundbreaking detail. Their next-generation diagnostics and interventions give us an unprecedented advantage in the fight against infection.
Dr. Hong Zhou gains unprecedented insight into the mechanisms of infection by using cryo-electron microscopy to create some of the world’s most detailed 3-D models of viruses, bacteria, and other biological complexes.
Dr. Jeffrey H. Miller studies how microorganism cells repair and mutate to maximize survival. He explores how we might leverage those processes to treat human disease.
Dr. Karin Nielsen’s international collaborations and evidence-based protocols have enabled at-risk countries to mobilize life-saving public health responses to devastating infectious diseases. Her work helps vulnerable areas build practical response infrastructures they can use to fight a variety of diseases.
Dr. Michael Yeaman studies natural processes and patterns to develop interventions that fight pathogens, overcome antibiotic resistance, and optimize immune health.