Arjun Deb, MD

Arjun Deb, MD
Email: adeb@mednet.ucla.edu
Lab website →

Cardiac repair · Extracellular matrix · Ectopic

The Deb lab is an interdisciplinary laboratory focused on the biology of cardiac wound healing. The lab uses a variety of genetic lineage tracing, and genetic and pharmacologic loss and gain of function approaches to understand how the heart heals following a heart attack. The lab studies the role of the extracellular matrix and cell-matrix cross talk in regulating wound healing. Another interest of the lab is to model genetic diseases in the dish using human pluripotent stem cells. Candidates interested in rotating or joining the lab would get wide exposure to animal physiology, human stem cell biology and disease in a dish modeling, extracellular matrix biology and understanding the role of metabolism in wound healing.

Publications

Yokota T, McCourt J, Ma F,Ren S, Li S,Kim TH, Kurmangaliyev Y, Ahadian S, Nasiri R, Nguyen T, Haw M, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Julian Whitelegge,Ryazantsev S, Khademhosseini A,Teitell MA,Chiou PY, Rowat AC, Crosbie RH, Pellegrini M, Seldin M,Lusis AJ, Deb A. Type V collagen in scar tissue regulates the size of scar after heart injury. Cell.2020Aug 6;182(3):545-562.e23. doi: 10.1016/j.cell.2020.06.030. Epub 2020 Jul 3. PubMed PMID: 32621799; PubMed Central PMCID: PMC7415659.

Pillai I, Li S, Romay M, Lam L, Lu Y, Jie Huang, Dillard N, Zemanova M, Rubbi L, Wang Y, Lee J, Xia M, Liang O, Xie Y, Pellegrini M, Lusis A, Deb A. Cardiac fibroblasts adopt osteogenic cell fates and contribute to pathologic heart calcification. Cell Stem Cell, 2017 20(2):218-232 PMID: [27867037].

Ubil E, Duan J, Pillai I, Rosa-Garrido M, Wu Y, Bargiacchi F, Lu Y, Stanbouly S, Huang J, Rojas M, Vondrinska T, Stefani E & Deb A. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature. 2014; 514: 585-590 [PMID 25317562].