• Gryphon Login
  • MyCourses
  • Alumni
  • UCLA Health
  • Contact Us
Prospective Students

Prospective Students

Prospective Students
  • Admissions
    Procedure & Timelines
    • Admissions Timeline
    • Admissions Procedure
    • Basis of Selection
    • COVID-19 Impacts on Admissions
    • Housing Information
    • Interview Process
    • Prerequisites
    General Information
    • Statement of Diversity
    • Mission Statement
    • Curriculum Resdesign
    • Honor Code
    • FAQs
    • Admissions Brochure
    • Admissions Timeline
    • Admission Procedure
    • Basis of Selection
    • Competencies
    • COVID-19 Impact on Admissions
    • DACA Applicants
    • DGSOM Mission Statement
    • FAQs
    • Honor Code
    • Housing Information
    • Interview Process
    • Statement of Diversity
    • Virtual Events
  • Outreach & Pipeline Programs
    Summer Pre-Health and Postbaccaluareate Programs
    • UCLA SHPEP
    • UCLA PREP
    • UCLA RAP
    Outreach and Recruitment
    • Conferences and Events
    • Stay Connected!
    • Contact Us
    • Conferences & Outreach Events
    • Summer Pre-Health and Postbaccalaureate Programs
    • Contact Us
    • Stay Connected
  • Financial Aid & Scholarships
  • Degrees & Programs
  • Curriculum
  • Student Life
    Why Choose UCLA
    • Research
    • Clinical Work
    • Service Opportunities
    • Global Health Impact
    • Why You'll Love LA
    Campus Life
    • Student Organizations
    • Annual Events
    • Day in the Life
    • Around Campus
    • Photo Galleries
    • Medical and Research News
    • Medical Student Council
    • Geffy Guide
    • Search Campus and Health News
    • Service Opportunities
    • Global Health Impact
    • Why You'll Love LA
    • Photo Galleries
    • Day in the Life
    • Around Campus
    • Medical and Research News
    • Search Campus and Health News
  • How to Apply
  • Gryphon Login
  • MyCourses
  • Alumni
  • UCLA Health
  • Contact Us

Prospective Students

Search Campus and Health News

Search Campus and Health News

Search Campus and Health News

  • Health News
  • A Day in the Life
  • Around Campus
  • Medical and Research News
  • Health News
  • A Day in the Life
  • Around Campus
  • Medical and Research News
  1. Home
  2. Prospective Students
  3. Student Life
  4. Search Campus and Health News

Search Campus and Health News

Share this

Health News

Title

High-fat diet leads to same intestinal inflammation as a virus

Health News

Date
06/21/2017
Article

FINDINGS

A new study by scientists at UCLA found that when mice eat a high-fat diet, the cells in their small intestines respond the same way they do to a viral infection, turning up production of certain immune molecules and causing inflammation throughout the body. The scientists also found that feeding the mice tomatoes containing a protein similar to that in HDL, or “good cholesterol,” along with the generic cholesterol drug Ezetimibe, reversed the inflammation.

The results could lead to new types of drugs, targeting the intestinal cells, to reduce people’s risk of heart attacks and strokes, or to treat other conditions linked to inflammation, including cancer and inflammatory bowel disease.

BACKGROUND

Researchers already knew that prolonged obesity can cause inflammation of the liver and fat tissues, and that this inflammation contributes to the development of diabetes and heart disease. Studies have also shown that higher levels of high-density lipoprotein, or HDL, cholesterol, reduces a person’s risk of heart disease.

The UCLA research team, led by Alan Fogelman, chair of the department of medicine at the David Geffen School of Medicine at UCLA, previously developed genetically engineered tomatoes that contained 6F, a protein resembling the main protein in high-density lipoprotein. In early experiments on 6F, they found that the compound was active in the small intestines of mice, and that it reduced inflammation. But exactly how it did this was unclear.

METHOD

The scientists fed either a standard chow or a high-fat, high-cholesterol Western diet to mice that were especially prone to developing clogged arteries. They also treated some of the mice with either 6F, in the form of a tomato concentrate containing the protein, Ezetimibe, or both. After two weeks, cells from the small intestines of the mice were collected and blood samples were taken. The researchers measured cholesterol levels as well as the levels of inflammatory and immune molecules in both the intestines and throughout the body.

IMPACT

The findings shed light on the molecular details of how high-fat diets cause inflammation in the body, by making the intestines activate the pathway normally triggered by a virus. This suggests that blocking this immune reaction — as 6F and Ezetimibe do — may treat inflammatory diseases and decrease people’s risk of heart attack and stroke.

AUTHORS

The authors of the study are all faculty and researchers at UCLA, affiliated with the Department of Medicine; Department of Molecular and Medical Pharmacology; Department of Human Genetics; Department of Microbiology, Immunology & Molecular Genetics; Department of Pathology and Laboratory Medicine; Department of Obstetrics and Gynecology; Semel Institute for Neuroscience and Human Behavior; and Department of Molecular, Cell and Developmental Biology. The first author is Pallavi Mukherjee; Fogelman is the senior author.

JOURNAL

The study was published June 7, 2017, in the Journal of Lipid Research.

FUNDING

The study was funded by the United States Public Health Service (2P01 HL-30568) and the Castera, Laubisch, and Milt Grey funds at UCLA.  

DISCLOSURES

Alan Fogelman, Mohamad Navab and Srinivasa Reddy are principals in Bruin Pharma, which is working to commercialize apoA-I mimetics, including the 6F peptide studied in this paper; Fogelman is additionally an officer of the company.

Like Us on Facebook Follow Us on Twitter Subscribe to Our Videos on YouTube Follow us on Instagram Connect with Us on LinkedIn Follow us on Pinterest Follow us on Flickr Follow us on Sharecare
Top 10 U.S. Medical Schools
  • Giving
  • Publications
  • Newsroom
  • Weekly Digest
  • Directory
  • Contact Us
  • Diversity
  • Emergency
  • Maps & Directions
  • UC Regents
  • Abuse Free
  • Volunteer
  • Biomed Library
  • Disability Resources
  • UCLA Health
  • Smoke-Free
  • Sitemap
  • Terms of Use
Top 10 U.S. Medical Schools
Like Us on Facebook Follow Us on Twitter Subscribe to Our Videos on YouTube Follow us on Instagram Connect with Us on LinkedIn Follow us on Pinterest Follow us on Flickr Follow us on Sharecare