Manish J. Butte, MD PhD is the E. Richard Stiehm Endowed Chair and Associate Professor in the Department of Pediatrics at UCLA, and Division Chief of Immunology, Allergy, and Rheumatology. Dr. Butte is clinically active, and is board certified in both Pediatrics and Allergy & Immunology. He cares for children and adults with rare immune diseases in the UCLA Immunology and Immunodeficiency Clinic. His lab focuses on understanding T cells, the major coordinating cells of the immune response, with a specific focus on mechanobiology. The group studies how mechanical forces influence T cells, with projects in cancer, infection, and diabetes. His lab has innovated tools and techniques in the use of biological atomic force microscopy (AFM) and 2-photon intravital microscopy to interrogate cells and tissues. The second major focus of his lab is in improving the diagnosis and treatment of genetic immune diseases. His lab has developed capabilities to study novel disease-causing mutations across a number of diseases in children and adults.