The Cardiovascular Research Theme at UCLA offers rodent models of cardiovascular disease as research resources to all researchers in the CV theme. The goal of this core is to provide CV theme researchers expertise and ready access to cardiac injury models for pre-clinical studies or mechanistic investigation of injury induced abnormalities affecting repair, scarring or electrical propagation. The surgical core services will be housed in the Center for Health Sciences building to enable easy access to the vivarium. Investigators will need to link their ARC protocol to the small animal surgical protocol maintained by the CV theme.
The following services are being currently offered:
- Mouse model of myocardial infarction induced by permanent ligation of the LAD
- Ischemia-reperfusion model of cardiac injury with 30-45 minutes of ischemic followed by reperfusion
- Transverse aortic constriction of the aorta
- Implantation of subcutaneous pumps for continuous infusion of drugs/reagents
- Cryo induced injury of the heart
- Blood pressure measurements (by cuff method)
- Electrocardiography (limb leads)
- Models of ectopic calcification
- Intra cardiac injection
- Vascular Injury (coming soon)
- Echocardiography (coming soon)
The CV theme core is committed to work with faculty, students, trainees and staff in the CV theme to generate new models of cardiac pathology. For inquiries or scheduling please contact Arjun Deb, MD, Director CV Research Theme at adeb@mednet.ucla.edu.
