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Dr. Yucheng Yao
Email: yyao@mednet.ucla.edu

Arteriovenous malformations · Vascular calcification · Vascular-related diseases

Our research focuses on several aspects of cardiovascular disease, such as cerebral and pulmonary arteriovenous malformations (AVMs) and the prevention of vascular calcification. We are also broadly interested in the vascular-related diseases, such as corticosteroid-associated osteoporosis and pulmonary fibrosis.

We have discovered that ill-fated cell transitions occurring in endothelial cells (ECs) play an essential role vascular disease and cause the ECs to become a source of pathological cells. To prevent or reverse this, we are creating novel approaches to shift the ill-fated ECs back to normal differentiation and re-gain functional capacities, which reverse the course of these disease processes.

We are combining several cutting-edge techniques to achieve the goals. We use molecular tools to examine human specimens and animal models to reveal pathological progression. By examining gene expression profile at single-cell resolution, we uncover the ill-fated differential trajectories in the cells and identify relevant target genes or genetic perturbations. With high throughput system, we screen small chemical compounds to target specific genes or signaling pathways. By using high-resolution imaging together with molecular biology approaches, we validate the effects of the compounds in cellular and animal models.

By using these approaches for disease targeting, our studies have successfully identified several compounds with effects on vascular calcification and AVMs. These compounds may be starting points for new therapeutic strategies and clinical translation.

Publications

  • Yao J, Guihard P, Blazquez Medela AM, Boström KI, Yao Y. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. Journal of Cell Biology. 216:3369-3385, 2017.
  • Yao J, Guihard P, Blazquez Medela AM, Yao J, Moon JH, Jumubay M, Boström KI, Yao Y. Serine protease activation essential for endothelial-mesenchymal transition in vascular calcification. Circulation Research. 2015; 117(9):758-769
  • Yao Y, Jumabay M, Ly A, Radparvar M, Cubberly MR, Boström KI. A role for the endothelium in vascular calcification. Circculation Research. 2013; 113(5): 495-504.
  • Yao Y, Yao J, Radparvar M, Blazquez-Medela AM, Guihard PJ, Jumabay M, Boström KI. Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency. Proc Natl Acad Sci U S A. 2013; 110(47):19071-19076.
  • Yao Y, Jumabay M, Ly A, Radparvar M, Wang AH, Abdmaulen R, Boström KI. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood. 2012, 119(21): 5037-47.
  • Yao Y, Jumabay M, Wang A, Boström KI. Matrix Gla protein deficiency causes arteriovenous malformations in mice. Journal of Clinical Investigation. 2011;121(8): 2993-3004. Yao J, Wu X, Zhang D, Wang L, Zhang L, Reynolds EX, Hernandez C, Boström KI, and Yao Y. Elevated Endothelial Sox2 Causes Lumen Disruption and Cerebral AVMs. Journal of Clinical Investigation. 129: 3121-3133, 2019.

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