• Gryphon Login
  • MyCourses
  • Alumni
  • UCLA Health
  • Contact Us
David Geffen School of Medicine at UCLA
David Geffen School of Medicine at UCLA
  • Patient Care
    • UCLA Health Mission & Vision
    • Discover Patient Stories
    • Search Locations
    • Find a Provider
    • Medical Services
    • UCLA Health Careers
    • UCLA Health Mission & Vision
    • Discover Patient Stories
    • Search Locations
    • Find a Provider
    • Medical Services
    • UCLA Health Careers
  • Research
    Departments, Centers & Institutes
    • Basic Science Departments
    • Clinical Departments
    • UCLA Research Centers
    • UCLA Research Institutes

    Researcher Resources
    • Core Facilities
    • UCLA CTSI
    • Faculty Profiles
    • Funding Information
    • Grants Submission Unit
    • Research Safety
    Researcher Administration
    • Clinical Trials
    • Research Policies & Procedures
    • Visa Information

    Professional Training
    • Graduate/Post Doctoral Training Programs
    • Office of Postdoctoral Affairs
    • Medical Education Research
    • MD Student Research Opportunities
    • Safety Resources
    Unified Research Themes
    • Cancer
    • Cardiovascular
    • Health Equity & Translational Social Science (HETSS)
    • Immunity, Inflammation, Infection, and Transplantation (I3T)
    • Metabolism
    • Neuroscience
    • Regenerative Medicine
    • South Tower Research Space

    Explore Research Innovation at the David Geffen School of Medicine
    Explore Research Innovation at UCLA Health

  • Education
    MD Education
    • Prospective Students
    • Current Students
    • Visiting Students
    • MD Alumni
    • Admissions
    • Financial Aid & Scholarships
    • Educational Evaluation & Assessment
    • MD Curriculum Redesign
    • MD Education FAQs
    • Student Website Change Request
    Residency Education
    • Incoming Residents
    • Current Residents
    • GME Community
    • GME Programs
    • STAR Program
    • Policies
    • Credentials Verification
    • Educational Evaluation & Assessment

    Postdoctoral Education

    Graduate Education
    • Programs in Bioscience
    • Biomathematics
    • Molecular Toxicology
    • Search UCLA Graduate Programs
    • Graduate Student Association

    Continuing Education

    • Live Courses
    • Online Courses
    • Resources
    • Prospective MD Students
    • Current MD Students
    • MD Curriculum Redesign
    • Residency Education
    • Postdoctoral Education
    • Educational Research & Evaluation
    • Graduate Education
    • Graduate Student Association
    • Continuing Education
  • Community
    Outreach
    • Community Engagement
    • Volunteer Opportunities
    • Service Opportunities
    • Global Health
    Student Life
    • Life at UCLA
    • MD Student Organizations
    • Annual Student Events
    • Peer Mentoring
    • Photo Galleries
    • Medical Student Council
    • Around Campus
    • Day in the Life
    • Medical and Research News
    • Search Campus and Health News
    • Geffy Guide
    • Global Health Program
    • Goals of Community Engagement
    • Volunteer Opportunities
    • Project Highlights
    • Happy Feet Clinic
    • Mobile Clinic Project
    • Allied Healthcare Career Guide
    • Community Partners in Care
  • Faculty
    Development
    • Faculty Professional Development
    • Faculty Executive Committee
    • Medical Education Committee
    • Faculty Handbook
    • Faculty & Staff Website Change Request
    Faculty Resources
    • Faculty Opportunities & Resources
    • Faculty Search
    • Departments
    • Room Reservations
    • Awards for Education
    • The Mellinkoff Award
    • Educational Affairs
    • My Courses
    • Gryphon
    • UCLA Simulation Center
    • Office of Diversity Affairs
    • Academic Affairs
    • Biomedical Library
    • Industry Relations
    • Emergency Preparedness
    • Faculty Professional Development
    • Evaluation & Assessment
    • Faculty Executive Committee
    • Medical Education Committee
    • Faculty Handbook
    • Faculty Profiles
    • Faculty & Staff Website Change Request
    • Faculty Opportunities & Resources
  • Equity and Diversity Inclusion
    Overview
    • About
    • Anti-racism Roadmap
    • Communities
    • Events
    • Health Equity
    • Resources
    Students
    • Education Resources
    • Conferences
    • First Gen Welcome
    • Mentoring
    • Road to Residency
    Faculty
    • Communities for Faculty
    • Conferences
    • Junior Faculty Lecture Series
    • Resources for Faculty
    • Anti-racism Roadmap
    • Communities
    • Health Equity
    • Resources
    • Events
  • About Us
    • History
    • Contact Us
    • Coronavirus Information
    • Cultural North Star
    • Dean's Corner
    • Leadership
    • Departments
    • Reporting and Support Resources
    • Maps & Directions
    • Geffen Hall
    • Financial Affairs
    • Get Social
    • LCME Accreditation
    • Academic Job Opportunities
    • Academic Affairs
    • Curricular Affairs
    • Office of Diversity Affairs
    • Emergency Preparedness
    • History
    • Contact Us
    • Dean's Corner
    • Executive Leadership
    • Finance & Administration
    • Geffen Hall
    • IT Connect
    • LCME Accreditation
    • Maps & Directions
    • Reporting and Support Resources
    • Get Social
    • Best Medical Schools Rankings
  • Giving
  • Gryphon Login
  • MyCourses
  • Alumni
  • UCLA Health
  • Contact Us

Julia J. Mack, PhD

Julia J. Mack, PhD
(310) 825-5749
Email: JMack@mednet.ucla.edu
Lab website →

Vascular Biology · Endothelial Cell Signaling · Mechanotransduction

The Mack Lab studies mechanisms of endothelial cell mechanotransduction in the context of cardiovascular health and disease. We investigate how mechanical forces influence blood vessel function, both at the single cell and tissue level. We are interested in the role of blood flow forces in controlling individual endothelial cell response within a monolayer of cells. To visualize the heterogeneity of response, we utilize high resolution live cell imaging and atomic force microscopy to measure plasma membrane fluidity, quantify the dynamics of Ca2+ signaling and immune cell binding, and determine the localization of proteins at the subcellular level. In addition, we utilize mouse models to understand the role of blood flow and dyslipidemia in the development of vascular inflammation and atherosclerosis.

Publications

  • Mack J.J., Mosqueiro T.S., Archer B.J., Jones W.M., Sunshine H., Faas G.C., Briot A., Arago´n R.L., Su T., Romay M.C., McDonald A.I., Kuo C-H., Lizama C.O., Lane T.F., Zovein A.C., Fang Y., Tarling E.J., de Aguiar Vallim T.Q., Navab M., Fogelman A.M., Bouchard L.S., Iruela-Arispe M.L., NOTCH1 is a Mechanosensor in Adult Arteries. Nature Communications 8, 1620 (2017).
  • Mack J.J. and Iruela-Arispe M.L., NOTCH Regulation of the Endothelial Cell Phenotype. Current Opinion in Hematology 25, 212 (2018).
  • Mack J.J., Youssef K., Noel O.D., Lake M.P., Wu A., Iruela-Arispe M.L., Bouchard L.S., Real-time Maps of Fluid Flow Fields in Porous Biomaterials. Biomaterials 34, 1980 (2013).

Full PubMed Bibliography

Like Us on Facebook Follow Us on Twitter Subscribe to Our Videos on YouTube Follow us on Instagram Connect with Us on LinkedIn Follow us on Pinterest Follow us on Flickr Follow us on Sharecare
Top U.S. Medical Schools in Primary Care
  • Giving
  • Contact Us
  • Diversity
  • Emergency
  • Maps & Directions
  • Publications
  • Directory
  • Report Misconduct
  • Volunteer
  • Biomed Library
  • Newsroom
  • Smoke-Free
  • Sitemap
  • Terms of Use
  • Report Broken Links
Top U.S. Medical Schools in Research
Like Us on Facebook Follow Us on Twitter Subscribe to Our Videos on YouTube Follow us on Instagram Connect with Us on LinkedIn Follow us on Pinterest Follow us on Flickr Follow us on Sharecare