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Keywords (not more than 3) cardiac neural control, mechanism of arrhythmias, visceral neuroscience
Dr. Shivkumar is an interventional cardiac electrophysiologist focusing on the neural control of the heart and mechanisms of arrhythmias in humans. His group has advanced neuraxial modulation treatment for patients with refractory ventricular arrhythmias in whom death was imminent. He and his colleagues identified that explanted stellate ganglia in patients with cardiomyopathy showed neural remodeling. In parallel, utilizing an integrative physiology approach and infarct models, his group has characterized neural remodeling, mechanisms of arrhythmias and mechanistic basis of neuraxial modulation. Recently his group has identified the ‘neural signature’ of cardiac injury, the consequence of altered afferent cardiac neurotransmission, that ultimately activates the neuroendocrine system which underlies heart failure and arrhythmias. ‘Myocardial+neural’ electrophysiological mapping that has been developed by his group paves the way for neuroscience-based therapies for the cardiovascular system. Understanding the function of the intrinsic nervous system of the heart (‘little-brain’) has major therapeutic implications. Dr. Shivkumar has assembled a team of physicians, scientists and engineers [the UCLA Neurocardiology Research Program of Excellence] to seek new knowledge in the molecular, cellular & network levels of cardiac neurobiology to develop globally applicable cardiac therapeutics and advance neurovisceral sciences.
3 Publications illustrative of the lab’s interests
PI Contact information: Email: KShivkumar@mednet.ucla.edu