Keywords (not more than 3)

Physiological Assessments & Screening

Heart Failure,

Translational Physiology

Dr. Roos directs the UCLA Mouse Physiology Core Lab. The lab and his research focus upon the physiological assessment of basic and translational cardiac function in rodent models. The core lab utilizes a wide range of invasive and non-invasive tools to assess animal models in a manner parallel to human assessments. These include echocardiography, ECG, EEG, pressure & vital sign monitoring, telemetric screening, HRV analyses, surgical manipulations, safety toxicology assessment, metabolic and exercise testing. Major research emphases have been on the evaluation of rodent models of heart failure and cardiac disease, circadian rhythm disturbances, ionic homeostasis, blood pressure regulation and regenerative treatments post MI. The current focus is primarily on the effects of electronic and conventional cigarette vapor exposure on cardiovascular function and pathology in mice. Since the lab’s inception, Dr. Roos has made contributions to a wide variety of studies at UCLA and elsewhere to better understand basic cardiac physiology as well as to better understand potential treatment strategies using various mouse models and investigative tools.

Publications:

1. Jordan, M.C., S.A. Henderson, T. Han, M.C. Fishbein, K.D. Philipson, K.P. Roos. 2010. Myocardial function with reduced expression of the sodium-calcium exchanger. J. Cardiac Failure, 16:786-796. PMID: 20797603. PMCID:PMC2929393.

2. Viola, H.M., M.C. Jordan, K.P. Roos, L.C. Hool. 2014. Decreased myocardial injury and improved contractility after administration of a peptide derived against the alpha-interacting domain of the L-type calcium channel. J. Am. Heart Assoc. 3(3):e000961. PMID:24958783.

3. Espinoza-Derout, J., Hasan, M.K., Shao, X.M., Jordan, M.C., Sims, C., Lee, D.L., Sinha, S., Simmons, Z., Mtume, N., Liu, Y., Roos, K.P., Sinha-Hikim, A.P., Friedman, T.C. 2019. Chronic Intermittent Electronic Cigarette Exposure Induces Cardiac Dysfunction and Atherosclerosis in Apolipoprotein E (ApoE) Knockout Mice. Am. J. Physiol. Heart & Circ. Physiol. 317(2):H445-H459. doi: 10.1152/ajpheart.00738.2018. Epub 2019 Jun 7. PMID: 31172811

 

PubMed Bibliography link: http://www.ncbi.nlm.nih.gov/sites/myncbi/1tCMrkzf8dTkE/bibliography/49102177/public/?sort=date&direction=ascending

PI Contact information: kroos@mednet.ucla.edu

Lab Website Link: http://www.physiology.ucla.edu/Labs/Mouselab.htm