Our lab is interested in the development and translation of multiscale imaging technology for cardiovascular applications. We apply radiomics to phenotype myocardial disease processes. Our current grant-funded work focuses on the development of USPIO-enhanced MRI for ischemic epicardial and microvascular coronary disease and on applications of MR technology in a spectrum of heart failure indications. Using percutaneous rapid prototyping technology, we have developed a swine model of hypoperfusion and ischemia for diagnostic steady-state myocardial blood volume mapping. In collaboration with radiology colleagues, we have demonstrated safety and efficacy for the diagnostic use of ferumoxytol in a wide array of cardiovascular applications and currently lead an international multicenter MRI registry (FeraSafe) for diagnostic use of ferumoxytol. We apply advanced MRI, MR spectroscopy, and cardiac ultrasound techniques to study diastolic dysfunction and heart failure mechanisms. We collaborate with data scientists to advance precision medicine by contributing quantitative imaging tools for phenotypic characterization of cardiovascular disease. Our research is supported by grants from the American Heart Association, National Institutes of Health, and the Veterans Health Administration.