Explore Research Innovation at UCLA Health
Neurobiology, Arrythmias, Heart failure
The autonomic nervous system plays an important role in the initiation and maintenance of arrhythmias. My research efforts focus on developing a detailed understanding of the basic mechanisms of cardiac arrhythmias. My labs overall goal is to develop neuromodulation therapies to treat arrhythmias as the degree of sympatho-excitation has been related to arrhythmias and sudden death. To this end, my lab has developed expertise in large and small animal models of heart failure and post-myocardial infarction VT, which closely mimics human conditions. We have shown that within the sympathetic neurons of the stellate ganglia, which is physically removed from the heart but is intricately involved in efferent regulation of cardiac function that there is significant structural and functional remodeling. We have established within both the porcine model of myocardial infarction and in humans with ischemic and non-ischemic cardiomyopathy, that neurochemical properties in these neurons are changed. My lab has expertise in a variety of in vivo and ex vivo techniques such as cardiac viral injections in mouse and pigs, multi-electrode and transmural cardiac electrical mapping, cardiovascular autonomic reflexes, neural recordings, neural networks, tissue clearing for confocal and super-resolution imaging and most recently RNAseq and its associated bioinformatic tools.
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