His research interests include genetic epidemiology, population genetics, membrane physiology, demography, oncology, medical imaging, stochastic processes, and optimization theory. Many of his landmark papers predate by a decade or more the current flood of biological applications of hidden Markov chains, Markov chain Monte Carlo, and high-dimensional optimization. He was the Chair of the Department of Human Genetics and the Department of Biomathematics (now Computational Medicine). He founded the GATP program in 2002, and was the PI for 15 years. He received the American Society of Human Genetics 2020 Motulsky-Childs Award for Excellence in Human Genetics Education, and was recently elected as a member of the National Academy of Sciences.

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