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UCLA Cardiovascular Research Theme

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UCLA Cardiovascular Research Theme

Rushi Parikh, MD

Rushi Parikh, MD
Email: rparikh@mednet.ucla.edu
Lab website

Heart Transplantation · Cardiac Allograft Vasculopathy · Endothelin-1

Dr. Parikh’s primary research focus is on the mechanisms of cardiac allograft vasculopathy, a complex immune and inflammatory-mediated disease of the graft coronary arteries that occurs following heart transplantation. His current Career Development Award from the American Heart Association aims to use contemporary invasive tools to prospectively evaluate the role of endothelin-1 in the development of cardiac allograft vasculopathy in heart transplant recipients through a comprehensive assessment of coronary anatomy, physiology, and vasomotor function. In addition, he has recently received industry-sponsored grants that will involve the use of emerging invasive imaging modalities including optical coherence tomography (Abbott Vascular) and near-infrared spectroscopy (NIRS) to further investigate plaque composition/development early after transplant and its impact on coronary physiology and outcomes. Previously, Dr. Parikh has examined the association of asymmetric dimethylarginine, a marker of nitric oxide-mediated endothelial dysfunction, with cardiac allograft vasculopathy.

 

Dr. Parikh’s other clinical research interests include fractional flow reserve and HIV-associated cardiovascular disease. He is also the Co-Assistant Director of the Interventional Cardiology Research Program and serves as a co-investigator on a number of clinical trials at UCLA.

Publications

  • Parikh RV,  Khush K, Pargaonkar V, Luikart H, Grimm D, Yu M, Valantine H, Yeung A, Fearon WF. Association of Endothelin-1 with Accelerated Cardiac Allograft Vasculopathy and Late Mortality Following Heart Transplantation. Journal of Cardiac Failure. 2018 Dec; pii: S1071-9164(18)30947-3.
  • Parikh RV,  Khush K, Luikart H, Sakarovitch C, Lee J, Desai M, Valantine H, Yeung A, Fearon WF. Usefulness of Asymmetric Dimethylarginine to Predict Outcomes After Heart Transplantation. American Journal of Cardiology. 2018 Aug 21; pii: S0002-9149(18)31640-0.
  • Parikh RV,  Khush K, Luikart H, Pargaonkar V, Kobayashi Y, Lee J, Sinha S, Cohen G, Valantine H, Yeung A, Fearon WF. Impact of Asymmetric Dimethylarginine on Coronary Physiology Early After Heart Transplantation. American Journal of Cardiology. 120(6): 1020-1025. Sept 2017.

Full Bibliography

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