Professor, Departments of Anesthesiology, Physiology and Medicine

Keywords (not more than 3) reflecting broad area of CV research, lab is interested in:

• Molecular signaling and systems biology
• Genetics and genomics regulation
• Cardiometabolic diseases pathophysiology and therapy

The long-term mission of Wang Lab is to understand how stress signaling leads to pathological changes in heart and metabolic system. Using systems genetic approaches and genomic tools, Wang Lab is conducting research in three major areas: 1). Investigating novel epigenetic regulators (lncRNAs and RNA-binding proteins) in stress-induced pathological remodeling and cellular responses in heart, fat and liver. 2). Discovering novel regulatory mechanisms in Branched-Chain Amino Acids metabolism in cellular nutrient signaling and pathophysiology. 3). Identify novel mechanism, therapeutic targets and developing novel therapies through systems genetics for heart failure and metabolic disorders.

Publications:

1. Yokota T, Li J, Huang J, Xiong Z, Zhang Q, Chan T, Ding Y, Rau C, Sung K, Ren S, Kulkarni R, Hsiai T, Xiao X, Touma M, Minamisawa S, Wang Y. p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart. J Clin Invest. 2020 Aug 31;. doi: 10.1172/JCI135859. [Epub ahead of print] PubMed PMID: 32573492.

2. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016 Oct;22(10):1131-1139. doi: 10.1038/nm.4179. Epub 2016 Sep 12. PubMed PMID: 27618650; PubMed Central PMCID: PMC5053883.

3. Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. 2016 May 24;133(21):2038-49. doi: 10.1161/CIRCULATIONAHA.115.020226. Epub 2016 Apr 8. PubMed PMID: 27059949; PubMed Central PMCID: PMC4879058.

Complete PubMed publications: https://www.ncbi.nlm.nih.gov/myncbi/1JKTUeqYLzo/bibliography/public/

PI Contact information: yibinwang@mednet.ucla.edu

Website link: https://www.mbi.ucla.edu/archives/faculty/yibin-wang