The long-term mission of Wang Lab is to understand how stress signaling leads to pathological changes in heart and metabolic system. Using systems genetic approaches and genomic tools, Wang Lab is conducting research in three major areas: 1). Investigating novel epigenetic regulators (lncRNAs and RNA-binding proteins) in stress-induced pathological remodeling and cellular responses in heart, fat and liver. 2). Discovering novel regulatory mechanisms in Branched-Chain Amino Acids metabolism in cellular nutrient signaling and pathophysiology. 3). Identify novel mechanism, therapeutic targets and developing novel therapies through systems genetics for heart failure and metabolic disorders.