Our research focuses on the electrical excitability of the brain ranging from molecules to behavior. We are investigating the function of voltage-gated ion channels that confer excitability on neurons, the effect of channel properties on cell and circuit firing patterns, the neural control of behavior, and the relationship between spike activity and neuronal viability.
Our lab is trying to overcome these barriers and resolve the structures of several channels and transporters. This is an ideal format for students to interact with other groups and learn numerous techniques through interdepartmental collaborations.
Research Interests & Expertise
The electrical excitability of the brain ranging from molecules to behavior
Issa, F.A., Mock, A.F., Sagasti, A., and Papazian, D.M. (2012) Spinocerebellar ataxia type 13 mutation associated with disease onset in infancy disrupts axonal pathfinding during neuronal development. Dis. Model. Mech. epub 26 June 2012 doi: 10.1242/dmm.010157.
Minassian, N.A.*, Lin, M.A.*, and Papazian, D.M. (2012) Altered Kv3.3 channel gating in early onset spinocerebellar ataxia type 13. J. Physiol. 590.7, 1599-1614. (*equal contributors)
Issa, F.A., Mazzochi, C., Mock, A.F., and Papazian, D.M. (2011) Spinocerebellar ataxia type 13 mutant potassium channel alters neuronal excitability and causes locomotor deficits in zebrafish. J. Neurosci. 31, 6831-6841.