Dr. Hoftman’s laboratory works in the areas of genetic and clinical high risk for psychosis, schizophrenia, neurodevelopment, imaging transcriptomics, and molecular neuroscience, with the goal of connecting the molecular underpinnings of disruptions in neural circuitry in psychosis risk to in vivo human brain development. Dr. Hoftman’s laboratory is sutdying genetic and environmental factors in youth at clinical high risk for psychosis, using novel neuroimaging methods and publicly available brain-wide transcriptomic atlases to investigate neurodevelopmental mechanisms of psychosis risk in a prospective longitudinal cohort of youth at clinical high risk for psychosis.


Clinical high risk, psychosis, schizophrenia, brain development, imaging transcriptomics, molecular neuroscience


  • Assistant Professor in Residence, Psychiatry and Biobehavioral Sciences
  • Division of Child and Adolescent Psychiatry
  • Neuromodulation Division
  • Member, Intellectual and Developmental Disabilities Research Center
  • Semel Institute for Neuroscience and Human Behavior
  • Member, Brain Research Institute
  • Genetics and Genomics GPB Home Area

Amir CM, Kapler S, Hoftman GD, Kushan L, Zinberg J, et al…Bearden CE. Substance use in youth at genetic and clinical high risk for psychosis. Frontiers in Psychiatry, 2023. 14; DOI: https://doi.org/10.3389/fpsyt.2023.1143315. PMID: 37151981.

Fiksinski A*, Hoftman GD*, Vorstman JAS#, Bearden CE#. A genetics-first approach to understanding autism and schizophrenia spectrum disorders: The 22q11.2 deletion syndrome. Molecular Psychiatry, 2022. doi: 10.1038/s41380-022-01783-5. *Co-first authors, #Co-last authors. PMID: 36192458.

Lin A*, Forsyth JK*, Hoftman GD*, Kushan-Wells L, Jalbrzikowski M, Dokuru D, et al., and Bearden CE. Transcriptomic profiling of whole blood in 22q11.2 reciprocal copy number variants reveals that cell proportion highly impacts gene expression. Brain Behavior Immunity Health, 2021. doi: 10.1016/j.bbih.2021.100386. *Co-first authors. PMID: 34841284.

Hoftman GD, Bazmi HH, Ciesielski AJ, Dinka LA, Chen K, Lewis DA. Postnatal development of glutamate and GABA transcript expression in monkey visual, parietal and prefrontal cortices. Cerebral Cortex, 2020. doi: 10.1093/cercor/bhaa342. PMID: 33279960

Hoftman GD, Dienel SJ, Bazmi HH, Zhang Y, Chen K and Lewis DA. Altered Gradients of Glutamate and GABA Transcripts in the Cortical Visuospatial Working Memory Network in Schizophrenia. Biological Psychiatry, 2018. 83;8:670-679. PMID: 29357982