UCLA researchers develop base editing approach for rare genetic immune disorder

New research indicates the novel gene editing technique base editing could be used as a one-time therapy to restore the production of T cells in patients born with the rare genetic immune disorder CD3 delta severe combined immunodeficiency.

This condition, also known as CD3 delta SCID, is caused by a mutation in the CD3 delta gene, which produces a protein by the same name that is critical to the formation of T cells. Babies born with CD3 delta SCID are unable to produce these white blood cells that fight against disease-causing intruders in the body.

To fight diseases of aging, scientist makes aging itself the target

When Dr. Ming Guo says that she wants to reverse the aging process, she’s not outlining a fantastical quest for the Fountain of Youth. She’s looking for ways to defeat incurable diseases.

“If we could pause, delay or even reverse aging, we would make a significant impact against numerous diseases,” said Guo, professor of neurology, molecular and medical pharmacology at the David Geffen School of Medicine at UCLA.“I want to create a higher quality of life over a healthy life span, rather than just prolonging life.”

Risk, resiliency in aging brain focus of $33.1 million grant

Susan Bookheimer, PhD, the Joaquin Fuster Distinguished Professor of Psychiatry and Biobehavioral Sciences at the UCLA David Geffen School of Medicine, is co-principal investigator for a newly awarded nationwide study that will investigate what keeps our brains sharp as we age, and what contributes to cognitive decline. The study will be performed by researchers from UCLA, Washington University School of Medicine in St. Louis, Harvard University/Massachusetts General Hospital and the University of Minnesota.

  • February 23, 2022
  • Research News

From UCLA Health: Presenting the case of a woman with HIV-1 in remission following specialized stem cell transplantation for leukemia

UCLA researchers presented today the first case of a U.S. woman living with HIV-1 that is in remission after she received a new combination of specialized stem cell transplants for treatment of acute myeloid leukemia (AML). The oral abstract was presented at CROI 2022, the Conference on Retroviruses and Opportunistic Infections.

Doctors in space: UCLA fellowship prepares new generation of flight surgeons

As the frequency of space travel grows and humans inch ever closer to long-distance, interplanetary missions, the need for specially trained medical personnel who can support the health, safety and well-being of astronauts and other travelers aboard spacecraft and in extraterrestrial environments has become increasingly important.