Why do some human thermostats run differently than others?

Your brain works hard to keep your body temperature in check. 

New work from Stephanie Correa's lab at David Geffen School of Medicine at UCLA shows how precisely tuned that system really is. The team identified a specific population of hypothalamic neurons that control core body temperature and brown fat activity, all while leaving food intake & body weight untouched. 

That kind of specificity suggests the brain has dedicated circuits for temperature control rather than one general thermostat. Digging into how these circuits work, including how hormones shape them, could eventually help explain why some people's internal thermostats run differently than others. Even feeling hot is a sophisticated brain computation. 

Read the entire paper: Sex-Specific Thermoregulatory Effects of Estrogen Signaling in Reprimo Lineage Cells