Joint Seminars in Neuroscience Series

Neuroscience Research Building Auditorium (Room 132) 

Abstract: Emerging evidence highlights the muscle-to-brain axis as a critical regulator of cognitive aging and neurodegeneration. This talk explores how sex differences modulate peripheral muscle signaling and CNS exercise response, as well as their impact on brain health across the lifespan. Using integrative molecular and physiological approaches, we examine sex-specific trajectories in muscle-derived factors influencing neuroinflammation, synaptic integrity, and Alzheimer’s pathology. Understanding these sex-dependent pathways provides new insight into the systemic biology of brain aging and identifies potential targets for personalized interventions in Alzheimer’s disease.