Transplantation Research

Let's Help Organ Transplantation Recipients Lead Longer, Healthier Lives.

Organ transplantation can be a life-saving gift. Surgeons have developed advanced techniques to spare and transplant functional limbs and organs, offering patients the chance for restored health. However, the recipient's immune system and the grafted organ may be incompatible. and while immune-suppressing drugs can aid graft acceptance, they also increase the risk of infection or cancer.

The field of transplantation science has soared in recent decades, but even with the best surgical methods, there is no guarantee of long-term transplant success because of graft rejection. Meanwhile, there are not enough natural organs for transplant to go around. Transplant rejection often necessitates second transplants, compounding the organ shortage by putting patients back on the waiting list. In summary, there has never been a greater need for breakthroughs.

What if we could help more patients live longer, healthier lives by finding new and safer ways to prevent graft rejection? What if we could shorten the organ waiting list by discovering or inventing new ways to use injured organs instead of discarding them—or creating bionic and tissue-based organs in the laboratory?

UCLA Immunology, Inflammation, Infection, and Transplantation (I3T) faculty believe transplantation can improve and save patient lives. We're figuring out how to increase organ donations, use donated or laboratory-created organs, and improve the success and longevity of transplanted grafts without increasing the risk of infection or cancer.