Different Diseases from Differing Perspectives

The Make-Up Of Neurodegenerative Diseases

UCLA neuroscientists are studying neurodegenerative diseases from many different perspectives, from understanding the atomic structure of abnormal toxic proteins that accumulate in the brains of patients with a spectrum of neurodegenerative diseases to determining how the loss of function of some genes in other patients leads to disease.

Important Contributions

Many UCLA scientists have made important contributions to understanding how the brain ages, here are a few. Ultimately the goal of these studies is to use rationale approaches based on a deep understanding of these diseases to develop affective therapeutic approaches.

Ming Guo, MD, PhD
S. Thomas Carmichael, MD, PhD
David S. Eisenberg, PhD
X. William Yang, MD, PhD

 Ming Guo, MD, PhD

Spotlight Samantha Butler, PhD

Dr. Ming Guo is a neurologist, who treats patients, and research scientist studying how neurodegenerative diseases like Parkinson’s disease disrupt normal brain function and ultimately destroy neurons. This has enormous consequences for individuals, families and our society.

 

S. Thomas Carmichael, MD, PhD

Spotlight Ben Novitch, MMSc, PhD

Dr. Carmichael and his colleagues have shown that the brain can be repaired — and brain function can be recovered — after a stroke in animals. The discovery could have important implications for treating a mind-robbing condition known as a white matter stroke, a major cause of dementia.

 

David S. Eisenberg, PhD

Spotloght Linda Ming-Huei Liau, MD, PhD, MBA

A hallmark of many neurodegenerative diseases, including Parkinson’s and Alzheimer’s, is the abnormal aggregation of proteins into fibrils called amyloids. Dr. David Eisenberg, has been trying to visualize and determine structure of these amyloids.

 

X. William Yang, MD, PhD

Spotlight Ye Zhang, PhD

UCLA Neuroscientist X. William Yang, MD, PhD, merges human genetic findings and clinical observations from patients with cutting-edge genetic tools to study a variety of brain disorders, including Huntington’s, Parkinson’s, and Alzheimer’s diseases.

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